Differential Scanning Calorimetry Services

Canada Peptide provides differential scanning calorimetry (DSC) services that accurately measure endothermic and exothermic transitions of most sample types, including API, Formulations and other materials.

Additionally, we offer reference samples tailored to your requirements. These samples exhibit well-defined heat capacity across the temperature ranges to be scanned, ensuring precise and reliable results.

What is DSC?

DSC is a powerful analytical tool for characterizing the stability of proteins and other biomolecules in their native form, utilizing advanced thermodynamic models for precise analysis.

The DSC technique offers remarkable convenience, requiring minimal assay development, no labeling, and no immobilization. It enables the screening of large sample quantities at low concentrations, thereby conserving valuable materials. This method measures the heat change associated with a molecule’s thermal denaturation as it is heated at a constant rate. The resulting data provide invaluable insights for biopharmaceutical development, spanning protein engineering, pre-formulation, process development, and final product formulation, ultimately enhancing research productivity.

DSC provides valuable information about various physical and chemical processes, including:

• Glass transition temperatures
• Melting and crystallization temperatures
• Oxidation and reduction reactions
• Curing and cross-linking reactions
• Thermal stability and decomposition

DSC is widely employed in various industries, such as pharmaceuticals, polymers, and materials science. The technique is particularly useful for characterizing and optimizing materials, as well as understanding their thermal properties and behavior under different conditions.

The Benefits of DSC

Differential Scanning Calorimetry (DSC) is an essential analytical technique that provides deep insights into the stability and thermal behavior of biomolecules. Its versatility and precision make it invaluable in biopharmaceutical research, protein engineering, and formulation development. Below are the key benefits of DSC:

• Non-destructive and label-free: DSC analyzes biomolecules in their native state without the need for labeling or immobilization, preserving their natural properties.
• Minimal sample requirements: DSC requires only small quantities of sample, making it ideal for working with scarce or high-value biomaterials.
• High-throughput screening: DSC facilitates the rapid screening of numerous samples, enabling efficient evaluation of stability and thermal properties.
• Thermodynamic insights: The technique provides detailed data on enthalpy, heat capacity, and thermal transitions, supporting the optimization of biotherapeutic candidates.

By delivering accurate, reproducible results, DSC enhances decision-making across biopharmaceutical development, helping streamline processes and accelerate breakthroughs in therapeutic innovations.

Key Protein-Related Services We Supply

Our comprehensive protein-related services are designed to support biopharmaceutical development at every stage. From analyzing protein stability and interactions to optimizing purification processes, we deliver precise and efficient solutions for protein characterization, selection, and formulation, ensuring reliable results and accelerated progress in therapeutic development.

Our services include:

• Monitoring protein affinity, specificity and activity.
• Observing protein fusion and crystallization.
• Characterization and selection of the most stable proteins or potential candidates in biotherapeutic development and formulation.
• Studying protein-ligand interactions.
• Rapid optimization of purification and manufacturing conditions.
• Quick stability assays for target proteins to be used for screening.

Unlock Insights with DSC Analysis

DSC analysis is a vital tool for advancing biopharmaceutical research, offering precise insights into protein stability, interactions, and thermal properties. By leveraging this powerful technique, we help optimize formulations, streamline development, and enhance the success of your therapeutic projects. Trust DSC analysis to drive your scientific innovation forward.